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Isothermal titration calorimetry

Nuvisan’s isothermal titration calorimetry platform

Isothermal titration calorimetry (ITC) provides precise ligand-binding affinities and thermodynamic insights, with personalised support from our biophysics team for your experiments. ITC is considered the gold standard for measuring ligand-binding affinities in solution without labels. Beyond binding affinities, ITC reveals crucial thermodynamic parameters, including enthalpy (ΔH) and entropy (ΔS), offering insights into molecular binding from a single experiment. Our biophysics team supports you in designing and performing ITC experiments tailored to your individual needs.

Thermodynamic insights into molecular binding

Our experienced scientists leverage isothermal titration calorimetry (ITC) to provide you with direct insights into the thermodynamics of binding events. ITC uniquely determines key parameters – enthalpy (ΔH), entropy (ΔS), free energy (ΔG), steady-state affinity (KD) and stoichiometry – in a single experiment. Our experts offer precise analysis without requiring modifications to your molecules, using a broad range of buffer compositions to suit your specific needs. We support you in profiling hit clusters, stereoisomers and hit-to-lead projects, and in nominating hits for structural biology. Our team also characterises RNA–ligand binding through ITC.

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