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Formulation development of non-sterile dosage forms

Formulation innovation – offering possibility for IP 

We offer formulation development services with robust selection processes, leveraging expertise in creating successfully marketed topical products. Our experts, with in-depth knowledge of key techniques, provide detailed microstructure characterization and performance insights to help you understand your drug product and meet regulatory expectations. We extensively apply these techniques to complex topical products to support successful development. Development of non-sterile oral liquid formulation to support early-stage clinical trials is also offered by Nuvisan.

Scientist removing cream from a beaker in front of a manufacturing equipment

Topical liquid and semi-solids formulations

With centuries of combined experience in topical formulation development, Nuvisan offers a diverse toolbox of solutions and innovative approaches to meet the specific needs of any topical product. Our team is committed to ensuring that your project is delivered on schedule with excellent quality, from early-stage de-risking to late-stage troubleshooting.

We operate a 450 m² laboratory dedicated to topical drug formulation, divided into seven secure, isolated labs, including four equipped for handling highly potent molecules.

Guided by the target product profile (TPP) and preformulation data, we conduct formulation screening, stability evaluations (chemical, physical, and microbiological), and in vitro skin permeability studies to optimise formulations. Microstructure and sensory properties are also characterised. Preclinical in vitro toxicology testing is used to assess local tolerance as well while in vitro and in vivo models permit evaluation of pharmacologic effects in inflammatory and non-inflammatory skin diseases (e.g., imiquimod-induced psoriasis in mice). This comprehensive approach supports the creation of formulations that are adapted to the specific needs of the compound, indication and patient.

Nuvisan’s integrated approach guides the development of effective, well-tolerated and cosmetically elegant formulations, offering flexibility for both start-ups and big pharma.

Capsules

Nuvisan provides comprehensive capsule formulation services, including hard gelatin and hydroxypropyl methylcellulose (HPMC) capsules for immediate release. Our expertise encompasses preformulation studies and excipient selection. We develop capsules for early-stage clinical trials for various APIs, helping ensure stability, bioavailability and patient compliance. With a focus on quality and efficiency, Nuvisan delivers tailored solutions for clinical production.

 
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