Securing high-quality protein in sufficient amounts is crucial for a successful drug discovery project. We excel in the expression and production of both soluble and membrane proteins. Our services cater to a variety of applications, including biophysics, biochemical assays, cell-based assays and structural biology. By partnering with us, you ensure that your drug discovery efforts are backed by reliable, high-quality protein production tailored to your specific research needs.
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Central to each hit identification and optimisation process is the design and development of robust assays, often under defined biochemical conditions. Tailored to your specific needs, our experts set up biochemical assays across diverse targets using a wide range of technologies and read-out systems. We support high-throughput screening campaigns as well as hit-to-lead and lead optimisation processes.
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Cell-based assays offer a relevant biological context, making them essential for discovery and development. Our biology team supports you with disease-relevant models to identify leads and targets, even in high-throughput formats. We also validate your signalling pathways and mechanisms of action, and identify biomarker candidates to help ensure the success of your project.
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High-content analysis (HCA) offers detailed multiparametric insights into cellular phenotypic changes, mechanistic details and live-cell kinetics. Our HCA experts excel in setting up systems with stem cells, tumour spheroids and organoids. Leveraging our proprietary libraries of up to 3 million compounds, we deliver impactful data to support your drug discovery needs, including cell painting.
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We offer a state-of-the-art biophysical platform equipped with techniques like TSA, nanoDSF, SPR, MST, ITC and NMR. These tools enable comprehensive target binding analysis to provide you with deeper insights into molecular interactions and optimise compounds based on biophysical data.
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To profile your compounds, our versatile mass spectrometry platform offers comprehensive solutions for proteomics, antibody-drug-conjugate analytics and quality analysis of RNA and proteins. It enables precise screening of covalent binders, delivering detailed data on binding interactions and stoichiometry.
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Our structural biology platform supports in-depth analysis using techniques like macromolecular crystallography, NMR and cryo-EM. These methods deliver 3D structural information about your targets, helping provide insights into their mechanisms of action and aiding in the rational design of improved chemical matter.
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Our 2Go platforms provide quick access to assays and X-ray co-crystal structures of therapeutically relevant targets with your compounds of interest. We have developed robust protocols that help ensure rapid turnaround times and high-quality results to accelerate your drug discovery project.
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