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Chemistry

At Nuvisan, we recognise the pivotal role chemistry plays in modern drug discovery. Our life science chemistry services offer end-to-end support, from hit-to-lead and lead optimisation to scale-up, biotransformations and physicochemical characterisations. With a team of over 100 highly experienced scientists, we combine decades of expertise with cutting-edge facilities to transform your innovative ideas into actionable results. Whether through precise synthesis, advanced analytics or unique microbiological capabilities, we deliver tailored solutions for your drug discovery challenges, supported by robust logistics and state-of-the-art IT infrastructure. 
Scientist running a reaction under an inert atmosphere

Design and synthesis

We specialise in drug design and synthesis, offering services such as hit-to-lead, lead optimisation and discovery chemistry. Our chemists integrate ligand- and structure-based modelling and other data science tools during design cycles. Additionally, we provide synthetic chemistry services for client-designed compounds, route scouting and radiolabelling.

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Automatization allow samples to be analyzed 24 h per day; automatic workflows can both process, archive and dissseminate data to researchers inside and outside the company.

Purification and analytics

Our purification and analytics services offer advanced compound purification and characterisation for various projects. In our separation technology lab, we provide chiral and achiral analyses from milligrams to kilograms using high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC). Equipped with state-of-the-art nuclear magnetic resonance (NMR), mass spectrometry and optical analysis tools, we deliver rapid, high-quality results for structural elucidation, metabolite discovery and fragment screening. With secure, paper-free workflows and integrated IT systems, we ensure efficient and reliable service tailored to your needs.

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Photoredox chemistry required light to “penetrate” the reaction solution. Flow chemistry provides a large reaction mixture surface area that allows efficient capture of light to promote good reaction conversions.

Specialty chemistry

Nuvisan provides advanced scale-up and special technologies to support drug discovery, offering flexible solutions from milligram to kilogram-scale synthesis. We optimise routes, apply technologies like flow and photochemistry and handle high-pressure reactions to improve yields. Our physicochemical characterisation services helps ensure drug candidates meet ADMET and bioavailability requirements.

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A shaking rack with Erlenmeyer flasks containing fermentation experiments

Microbiological chemistry

Our microbiological chemistry team supports pharmaceutical and agricultural research by producing drug metabolites, performing preparative-scale biotransformations as well as upscaling proteins and plasmids. Our advanced fermentation platform enables process optimisation and scaling. Using a comprehensive biooxidation toolbox, we efficiently synthesise drug metabolites.

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A roller shelf cabinet with chemical building blocks

Logistics

Efficient logistics are crucial for preclinical research. We integrate substance and lab logistics for rapid turnaround times, supporting clients with ready-to-use formats, and manage over 40,000 building blocks. We offer flexible, traceable storage at various temperatures and handle compliant shipping, including export, import and specialised shipments.

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