Scientific publications

• 2025

  Author	Title	Journal	Link
  Borrallo-Lopez, L. et al.	Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women.	Int J Parasitol Drugs Drug Resist 27, 100582 (2025)	https://doi.org/10.1021/acs.jmedchem.2c02082
  Timmerman, P. et al.	Feedback from a workshop by the European Bioanalysis Forum on assay validation requirements for in vitro assays following the publication of ICH M12 guideline – a plea for context-of-use over ICH M10 standards.	Bioanalysis 1–4 (2025)	https://doi.org/10.1080/17576180.2025.2468596
  Blondeel, E. et al.	The Spheroid Light Microscopy Image Atlas for morphometrical analysis of three-dimensional cell cultures	Sci Data 12, 283 (2025)	https://doi.org/10.1038/s41597-025-04441-x
  Li, H. Z. et al.	Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2.	Nat Commun 16, 721 (2025)	https://doi.org/10.1038/s41467-025-55942-7

   

• 2024

  Author	Title	Journal	Link
  Goodwin, L. et al.	The use of surrogate matrices in bioanalytical preclinical safety testing using chromatographic methods: a recommendation from the European Bioanalysis forum.	Bioanalysis 16, 1199–1202 (2024)	https://doi.org/10.1080/17576180.2024.2416360
  Arfvidsson, C. et al.	Moving into the cloud: a summary from a European Bioanalysis forum workshop on introducing cloud applications in bioanalytical laboratories.	Bioanalysis 16, 1203–1206 (2024)	https://doi.org/10.1080/17576180.2024.2416357
  Schiedel, M. et al.	We are MedChem: The Frontiers in Medicinal Chemistry 2024.	ChemMedChem 19, e202400543 (2024)	https://doi.org/10.1002/cmdc.202400543
  Hsiao, W.-K. et al.	Opportunities of topical drug products in a changing dermatological landscape.	Eur J Pharm Sci 203, 106913 (2024)	https://doi.org/10.1016/j.ejps.2024.106913
  Hohlbaum, K. et al.	The implementation of tunnel handling in a mouse breeding facility revealed strain-specific behavioural responses.	Lab Anim 58, 552–564 (2024)	https://doi.org/10.1177/00236772231215077
  Li, F. et al.	CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein.	J Chem Inf Model 64, 8521–8536 (2024)	https://doi.org/10.1021/acs.jcim.4c01267
  Purzner, J. et al.	Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma.	Preprint at https://doi org/10 1101/2024 11 21 624171 (2024)	https://doi.org/10.1101/2024.11.21.624171
  Vakalopoulos, A. et al.	Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance.	J Med Chem 67, 19165–19187 (2024)	https://doi.org/10.1021/acs.jmedchem.4c01590
  Garaizar, A. et al.	Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments.	Proc Natl Acad Sci U S A 121, e2404555121 (2024)	https://doi.org/10.1073/pnas.2404555121
  Streckfuss‐Bömeke, K. et al.	Physiologists as medical scientists: An early warning from the German academic system.	Physiol Rep 12, e70055 (2024)	https://doi.org/10.14814/phy2.70055
  Goodman, J. et al.	Re-thinking the current paradigm for clinical immunogenicity assessment: an update from the discussion in the European Bioanalysis Forum.	Bioanalysis 16, 905–913 (2024)	https://doi.org/10.1080/17576180.2024.2376949
  Cowan, K. J. et al.	The European Bioanalysis Forum recommendation on establishing appropriate drug tolerance levels in antidrug antibody assays.	Bioanalysis 16, 915–921 (2024)	https://doi.org/10.1080/17576180.2024.2376950
  Schaefer, M. et al.	Surface-mutagenesis strategies to enable structural biology crystallization platforms.	Acta Crystallogr D Struct Biol 80, 661–674 (2024)	https://doi.org/10.1107/s2059798324007939
  Rauh, U. et al.	BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models.	Nat Cancer 5, 1479–1493 (2024)	https://doi.org/10.1038/s43018-024-00814-0
  Cowan, K. J. et al.	A European Bioanalysis Forum recommendation for requiring a context-of-use statement for successful development and validation of biomarker assays.	Bioanalysis 16, 835–842 (2024)	https://doi.org/10.1080/17576180.2024.2376436
  Gelová, Z. et al.	Protein Binder Toolbox for Studies of Solute Carrier Transporters.	J Mol Biol 436, 168665 (2024)	https://doi.org/10.1016/j.jmb.2024.168665
  Graham, K. et al.	Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.	Cell Chem Biol 31, 1247-1263 e16 (2024)	https://doi.org/10.1016/j.chembiol.2024.02.013
  Hanckmann, E. et al.	Feedback from the Science Café roundtables at the ninth European Bioanalysis Forum Young Scientist Symposium: optimizing the work–life balance in a bioanalytical laboratory.	Bioanalysis 16, 569–574 (2024)	https://doi.org/10.4155/bio-2024-0054
  Karsten, C. B. et al.	Macrophage- and CD4+ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity.	PLoS Pathog 20, e1012190 (2024)	https://doi.org/10.1371/journal.ppat.1012190
  Begou, O. et al.	An interview with Bioanalysis : speaking with the 2023 Reid bursary award winners – part 2.	Bioanalysis 16, 221–225 (2024)	https://doi.org/10.4155/bio-2024-0051
  Viant, M. R. et al.	Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice.	Arch Toxicol 98, 1111–1123 (2024)	https://doi.org/10.1007/s00204-024-03680-y
  Zenklusen, I. et al.	Effect of Daridorexant on the Pharmacokinetics of Midazolam, and on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Male Subjects.	Drugs R D 24, 97–108 (2024)	https://doi.org/10.1007/s40268-024-00456-8
  Wilhelmi, P. et al.	Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish.	Arch Toxicol 98, 943–956 (2024)	https://doi.org/10.1007/s00204-023-03655-5
  Tug, T. et al.	In vivo alkaline comet assay: Statistical considerations on historical negative and positive control data.	JPT 148, 105583 (2024)	https://doi.org/10.1016/j.yrtph.2024.105583
  Timmerman, P. et al.	Recommendations and Feedback from the European Bioanalysis Forum Workshop: 1 Year Into ICH M10 – Keeping Our Finger on the Pulse.	Bioanalysis 16, 259–270 (2024)	https://doi.org/10.4155/bio-2024-0013
  Sugawara, T. et al.	Dual targeting of the androgen receptor and PI3K / AKT / mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis.	Mol Oncol 18, 726–742 (2024)	https://doi.org/10.1002/1878-0261.13577
  Kamp, H. et al.	Utility of in vivo metabolomics to support read-across for UVCB substances under REACH.	Arch Toxicol 98, 755–768 (2024)	https://doi.org/10.1007/s00204-023-03638-6
  Voeltz, D. et al.	A parametric additive hazard model for time-to-event analysis.	BMC Med Res Methodol 24, 48 (2024)	https://doi.org/10.1186/s12874-024-02180-y
  Falkenstern, L. et al.	A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition	Sci Rep 14, 1739 (2024)	https://doi.org/10.1038/s41598-023-50964-x
  Aquilanti, E. et al.	Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression.	Neuro-oncol Adv 6, vdae115 (2024)	https://doi.org/10.1093/noajnl/vdae115

• 2023

  Author	Title	Journal	Link
  Schneidewind, S. J. et al.	Rumination Detection in Sheep: A Systematic Review of Sensor-Based Approaches.	Animals 13, 3756 (2023)	https://doi.org/10.3390/ani13243756
  Becker, A. et al.	Phase I crossover study of DNA‐protein kinase inhibitor peposertib in healthy volunteers: Effect of food and pharmacokinetics of an oral suspension.	Clinical Translational Sci 16, 2628–2639 (2023)	https://doi.org/10.1111/cts.13657
  Heller, S. et al.	Pan-PI3K inhibition with copanlisib overcomes Treg- and M2-TAM-mediated immune suppression and promotes anti-tumor immune responses.	Clin Exp Med 23, 5445–5461 (2023)	https://doi.org/10.1007/s10238-023-01227-6
  Gehringer, M. et al.	Back in Person: Frontiers in Medicinal Chemistry 2023.	ChemMedChem 18, e202300344 (2023)	https://doi.org/10.1002/cmdc.202300344
  Raturi, S. et al.	High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies.	JoVE 65878 (2023)	https://doi.org/10.3791/65878
  Neves, M. et al.	Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments.	J Biomed Semant 14, 13 (2023)	https://doi.org/10.1186/s13326-023-00292-w
  Langer, G. et al.	Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor.	Mol Pharm 104, 105–114 (2023)	https://doi.org/10.1124/molpharm.122.000662
  Billié, S. et al.	Identification of unknown impurities J, RRT 2.2, 2.4, 2.6 and 3.4 in tetralysal® capsules.	Eur J Pharm Sci 188, 106519 (2023)	https://doi.org/10.1016/j.ejps.2023.106519
  Yalkinoglu, Ö. et al.	Assessment of the potential of the MET inhibitor tepotinib to affect the pharmacokinetics of CYP3A4 and P-gp substrates.	Invest New Drugs 41, 596–605 (2023)	https://doi.org/10.1007/s10637-023-01378-z
  Borek, B. et al.	Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy.	Mol Cancer Ther 22, 807–817 (2023)	https://doi.org/10.1158/1535-7163.mct-22-0721
  Ali, A. et al.	European Medicinal Chemistry Leaders in Industry (EMCL) – On the Status and Future of Medicinal Chemistry Research in Europe**	ChemMedChem 18, e202300127 (2023)	https://doi.org/10.1002/cmdc.202300127
  Vakalopoulos, A. et al.	New Generation of sGC Stimulators: Discovery of Imidazo[1,2- a ]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.	J Med Chem 66, 7280–7303 (2023)	https://doi.org/10.1021/acs.jmedchem.2c02082
  Duman, C. et al.	Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion.	Cell Death Dis 14, 296 (2023)	https://doi.org/10.1038/s41419-023-05813-0
  Grünewald, S. et al.	Effects of regorafenib on the mononuclear/phagocyte system and how these contribute to the inhibition of colorectal tumors in mice.	Eur J Med Res 28, 147 (2023)	https://doi.org/10.1186/s40001-023-01099-2
  Schnerwitzki, D. et al.	Adapting the pantograph limb: Differential robustness of fore- and hindlimb kinematics against genetically induced perturbation in the neural control networks and its evolutionary implications.	Zoology 157, 126076 (2023)	https://doi.org/10.1016/j.zool.2023.126076
  Göricke, F. et al.	Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21.	Med Chem 66, 3431–3447 (2023)	https://doi.org/10.1021/acs.jmedchem.2c01933
  Zablowsky, N. et al.	High Throughput FISH Screening Identifies Small Molecules That Modulate Oncogenic lncRNA MALAT1 via GSK3B and hnRNPs.	ncRNA 9, 2 (2023)	https://doi.org/10.3390/ncrna9010002
  Orsi, D. L. et al.	Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.	Bioorg Med Chem 78, 117130 (2023)	https://doi.org/10.1016/j.bmc.2022.117130
  Ackloo, S. et al.	Target 2035 – an update on private sector contributions.	RSC Med Chem 14, 1002–1011 (2023)	https://doi.org/10.1039/d2md00441k