• contact us navContact Us
  • search navSearch

Discovery DMPK

Research in drug metabolism and pharmacokinetics (DMPK) is crucial for drug development, offering insights into how drugs are absorbed, distributed, metabolised and excreted (ADME) in the body. This research optimises drug efficacy, minimises toxicity and predicts potential side effects. Understanding metabolic pathways and drug stability enables the design of safer, more effective treatments, supports personalised medicine by predicting genetic variations in drug response and assesses the risk of drug-drug interactions. Overall, DMPK is integral to the success of drug candidates in clinical trials and their safe market use.  

Our services cover the entire DMPK spectrum, from discovery bioanalysis and in vitro PK and DDI to in vivo DMPK, biotransformation and metabolite identification (MetID). We also offer consultancy services and isotope chemistry. Using state-of-the-art technologies, we aim to provide reliable data to support the development of safe and effective drugs. Committed to quality and efficiency, we work closely with you to design solutions that meet your goals.
Liver model in a jar surrounded by vials and beakers

In vitro DMPK

Explore our in vitro DMPK services for drug discovery, featuring state-of-the-art assays for in vitro metabolic stability, permeability and transporters, protein binding and blood partitioning, CYP inhibition and CYP induction. We deliver rapid, reliable and high-quality data, along with scientific support to explain results and suggest appropriate screening strategies to overcome ADME liabilities.

learn more
Cells actively metabolizing substances

In vivo DMPK

Our interdisciplinary team of in vivo PK scientists uses multiple in vivo models to provide all the data needed for compound optimisation and clinical candidate selection. Our DMPK experts optimise study designs to best suit your needs. We also offer tailor-made studies for specific ADME questions, such as tissue distribution and elimination studies. Our work adheres to high standards for animal welfare, aligned with the 3R concept and AAALAC accreditation.

learn more
Scientists discussing a graph in a meeting room

Consultancy services

DMPK consultancy is crucial in early-stage drug development, offering expertise in optimising the pharmacokinetic properties of drug candidates. Our experienced PhD-level DMPK scientists provide consultancy for all stages of your drug discovery project, from hit identification to preclinical candidate profiling. Identifying the ADME characteristics of compounds at this stage is essential for predicting their behaviour in the body and addressing DMPK-related development risks early.

learn more
Evaluation of MS performance

Discovery bioanalysis

Optimise your molecule with our bioanalytical services, designed for high-quality quantitation of drugs and their metabolites in various biological matrices. With decades of experience in discovery bioanalysis, our expert team delivers accurate and precise results on schedule to support your drug discovery and development projects. Our scientists offer insights that enable tailored solutions for your needs, from target identification and validation to lead optimisation and in-depth characterisation of clinical candidates.

learn more
 
v.1.1.1203