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Preformulation

Early-stage formulation solutions

At Nuvisan, we provide advanced preformulation services to support successful drug development. Our approach includes analysing physical, chemical and biological properties to guide formulation design while supportingstability, performance and scalability for non-sterile liquid and topical dosage forms. Close collaboration between the chemical development and formulation science departments generates solid-state, solubility and compatibility data, laying the foundation for efficient, effective and innovative formulation development.

Two female scientists standing in front of a stirring equipment on a bench

Solubility and compatibility analysis

Nuvisan provides comprehensive drug substance (DS) solubility and compatibility profiling using advanced techniques like Ultra-Performance Liquid Chromatography (UPLC) with a diode array detector (DAD). We analyse both single excipients and mixtures, enabling rational excipient selection and formulation design. This data helps optimise API solubility, stability, and skin delivery while considering tolerance and sensory aspects.

Our efficient R&D approach generates solubility and compatibility profiles with key ingredients, facilitating rapid formulation development. These well-defined profiles allow our experts to quickly select the most appropriate formulation technologies and create customised compositions tailored to your molecule's specific needs.

Whether you require end-to-end development for a commercial formula or exploratory formulations, Nuvisan adapts formulations to fit your molecule's physicochemical properties, ensuring swift project advancement. Our continuously updated formulation science and technology library supports our innovative approach, making Nuvisan a leader in efficient and effective topical and oral liquid product development.

 

Preliminary degradation tests

Forced degradation screening helps identify ideal formulation conditions, such as preferred pH, and indicates the need for stabilisers like antioxidants. This critical process is carried out in close collaboration between our chemistry and analytics teams.

Nuvisan's complementary, high-tech, and express approach involves cros-functional teams of formulators, chemists, and analysts, shortening development timelines and accelerating your projects to proof-of-concept studies.

 
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