PhysChem

Understanding drug properties

Physicochemical characterisation (PhysChem) is crucial for optimising drug candidates during discovery. Key properties like lipophilicity, solubility and stability provide insights into DMPK parameters such as permeability and bioavailability. These measurements are foundational for ADMET characterisation and are tailored to fit both the “rule of five” and beyond. In collaboration with our Digital Life Sciences unit, we help refine your compounds for successful development.

A rack of samples for HPLC analysis

Physicochemical characteriation (PhysChem)

Our advanced platforms offer a comprehensive range of services:

Lipophilicity assessment
- High-throughput logD determination using HPLC-based systems.
Solubility screening
- Rapid kinetic solubility assays (DMSO-based).
- Thermodynamic solubility in biorelevant media (FaSSIF, FeSSIF, FaSSGF).
Stability studies
- Degradation analysis in varying pH, heat, oxidative and gastric juice conditions.
- Reactivity assessments for covalent binders (glutathione, cysteine).
Specialised characterisation
- Crystallinity (XRPD) and polar surface area (EPSA)
- Tailored packages for PROTAC^®s, peptides and macrocycles.

These services ensure your drug candidates are optimised for in vivo studies and beyond.