Scale-up and advanced techniques

Scaling drug discovery

Scaling up compounds is a critical step in drug discovery, bridging small-scale synthesis and multi-kilogram production. At Nuvisan, we provide expertise in synthetic design, process optimisation and the application of advanced technologies to overcome challenges. With flexible solutions, state-of-the-art facilities and GLP-certified processes, we ensure your project is delivered efficiently and tailored to your requirements.

Scale-up and advanced techniques

Our chemists combine scale-up expertise and advanced techniques to seamlessly transition your chemical projects from lab-scale to production.

Scale-up expertise

Transition of compounds from milligrams to kilograms with route optimisation
Route scouting and safe reagent alternatives (e.g., pyrophoric substances)
Purification methods, that includes:
- Recrystallisation, chromatography and high-throughput preparative HPLC
- Chiral resolution for enantiomeric purity
- Collaborative analysis with CoA certification to help ensure quality
- Building block synthesis, toxicological batches and GMP manufacturing.

Advanced Techniques

Flow and photochemistry
- Customised photoreactors for batch and flow (photoflow) modes
- Controlled conditions for higher yields and shorter reaction times
- Advanced flow chemistry to efficiently handle unstable intermediates.
High-pressure reactions
- Gas reactions (e.g., hydrogenation) at up to 100 bar
- Reaction scale-up from milligrams to hundreds of grams
- Parallelised chemistry for rapid optimisation and development.
Plate-based chemistry/direct-to-biology
- Nano-scale synthesis of compound libraries on 96-well plates.