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In vivo DMPK

Why in vivo metabolism is key

Creating compounds with a strong pharmacokinetic profile can be challenging. With decades of combined expertise in DMPK, our interdisciplinary team of scientists and lab professionals can identify relevant DMPK liabilities for you. We offer a range of assays and in vivo models to provide all the data needed for your compound optimisation and clinical candidate selection.

Female scientist wearing lab goggles operating a speedvac machine

Understanding your drug candidates` behavior in vivo

In vivo DMPK compiles the pharmacokinetic (PK) profile of your compound. We utilise various application methods in our in vivo models to measure plasma and tissue levels of the test compound, analysed by LC-MS/MS or HPLC-UV. Depending on your compound profile and needs, we offer diverse study designs, determining parameters such as clearance, elimination half-life, Tmax, Cmax and bioavailability. We also provide blood-to-plasma ratio assays in-house for calculating blood clearance. More detailed studies examine distribution in target tissues, crossing physiological barriers like the blood-brain barrier, and compound excretion.  
 
Data and reports can be provided in Phoenix WinNonlin, Microsoft Excel, Word or PowerPoint, and customised to your needs. We conduct high-quality PK studies in mice, rats and dogs. Microsampling enables a full plasma-time concentration profile from one animal while maintaining high animal welfare standards. Depending on your requirements, you can choose between naïve or catheterised animals. We offer all standard administration routes, including intravenous (bolus or infusion), oral, subcutaneous and others. We are open to addressing your specific research questions.  
 
Dosing can be done as a single compound or in cassette dosing (up to four compounds plus a reference). Tailor-made studies for specific absorption, distribution, metabolism and excretion (ADME) questions include:  

  • Tissue distribution studies (cold compound) from the same animal
  • Bile duct-cannulated rats and compound administration via portal vein infusion  
  • Metabolic cage studies to investigate excretion pathways
  • Studies to test and compare different formulations (including formulation development, preparation and analysis) 
  • Multiple dosing to investigate the compound in a steady state.

We uphold the highest standards of animal welfare, adhering to the 4R principles and holding AAALAC accreditation.

 
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