Our biomarker discovery services include both hypothesis-free global and mode-of-action hypothesis-driven approaches, tailored to your research needs. We employ a complementary strategy by generating data from both preclinical models and human samples, ensuring comprehensive and reliable insights for your projects.
Unlock unparalleled insights with our next-generation sequencing (NGS) at single-cell resolution. Decode cellular heterogeneity to uncover rare and unique biomarkers, and discover gene expression signatures that drive disease progression and therapy response. By integrating data across transcriptomics, epigenomics, and genomics, we provide multidimensional insights that pinpoint cellular pathways and states with precision. From identifying novel therapeutic targets to tracking treatment outcomes, single-cell sequencing is revolutionising biomarker discovery, ensuring your research is at the forefront of scientific innovation.
Proteomics, the study of proteins and their functions, structures and interactions, is rapidly advancing and crucial for understanding disease mechanisms, drug discovery and personalised medicine. Our team has extensive expertise in proteomic analysis and data integration, helping you unravel the complexity of biological systems. Through cutting-edge techniques and innovative approaches, we are dedicated to solving your scientific challenges and advancing your research.
Cytokine profiling is essential for understanding immune responses and disease pathways, helping to analyse complex cytokine networks and reveal disease-specific patterns. This technique identifies biomarkers for cancers, autoimmune diseases and infections while tracking immune modulation in response to therapies with high precision. Using high-throughput multiplex assays, we offer comprehensive and cost-effective profiling. From pinpointing inflammation markers to exploring therapeutic targets, cytokine profiling plays a crucial role in biomarker discovery. Our services include profiling for oncology, immunology/ inflammation (cytokines/chemokines), and other indications using platforms such as Mesoscale), homogeneous time-resolved fluorescence (HTRF) and enzyme-linked immunosorbent assay (ELISA).
Flow cytometry is essential for next-generation biomarker discovery, supporting your research in cancer, immunology and more. It offers high-throughput, multiparametric analysis to identify unique cellular markers and single-cell resolution to uncover rare populations and subtle changes. Our advanced technology, including spectral flow cytometry, measures functional biomarkers like cytokine production and signalling proteins, providing deeper profiling and enhanced discovery. Partner with us for comprehensive insights and advanced solutions tailored to your research needs.
Immunohistochemistry (IHC) is an invaluable tool for identifying and validating new drug targets, characterising disease pathology, and assessing drug efficacy in both preclinical models and clinical trials. It also supports patient selection based on biomarker profiles, facilitating more targeted and personalised treatments.
We provide spatial profiling using multicolour immunofluorescence to identify various immune cells infiltrating a tumour, including T cells, B cells, natural killer cells and myeloid-derived suppressor cells. Our expertise includes the use of multiple established markers for both immunofluorescence (IF) and immunohistochemistry (IHC).
We offer RNA in situ hybridisation using RNAscope™ technology, enabling the in situ detection and quantification of single RNA molecules, and providing precise spatial gene expression results for your research needs. This technology also allows us to cross-validate antibodies for immunohistochemistry (IHC) or serve as an alternative assay when suitable antibodies for IHC are unavailable. To support your research fully, we provide single and dual fluorescent and chromogenic stainings, as well as dual IHC-RNAscope™ duplex staining, for the detailed analysis of preclinical and clinical samples.
Proximity ligation assays are invaluable for studying endogenous protein-protein interactions in situ, providing critical insights into cellular functions. We offer these assays, along with tailored assay development for your specific targets, ensuring precise and insightful results for your research.
Quantitative real-time polymerase chain reaction (qRT-PCR) is a highly sensitive and specific technique for measuring gene expression levels in biological samples. Its rapid and cost-effective nature makes it ideal for high-throughput screening of biomarker responses to potential drug candidates. To support your research, we offer qPCR profiling of preclinical and clinical samples in a 384-well format, ensuring efficient and accurate results.
Protein expression profiling is essential for understanding cellular processes and identifying potential therapeutic targets. We offer protein expression profiling of preclinical and clinical samples using Simple Western technology, including Simple Western Jess and Peggy Sue. This advanced technology automates the protein separation and immunodetection processes of traditional Western blotting, eliminating many error-prone steps and ensuring accurate, reliable results for your research.
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