Inflammation and immunology platform

Advance your drug discovery with our immunology and inflammation in vivo models

Our tailored in vivo models for immunology and inflammation provide reliable preclinical solutions to accelerate your drug discovery program. Emphasising scientific accuracy, translational relevance, PK/PD relationships and customised study designs, we ensure rigorous evaluation of your therapeutic candidates. Our immunology services are led by scientists who have a decade of pharma industry experience, broad expertise in autoimmune disorders and a proven track record in translating drug discovery into the clinic. Partner with us to unlock the potential of your treatment options and offer innovative solutions faster.

Key role of inflammatory immune response in diseases

In vivo models of immunology and inflammation

Acute inflammation models (PD models) – evaluate anti-inflammatory therapies with our robust acute models:

LPS-induced peritonitis (mouse/rat)
MDP-induced peritonitis (mouse/rat)
Hapten-induced DTH response (mouse/rat).

Arthritis models – mimic chronic joint inflammation and tissue damage:

Adjuvant-induced arthritis (rat)
Collagen antibody-induced arthritis (mouse).

Respiratory models – address airway inflammation and pulmonary diseases:

Eosinophilic asthma (HDM-induced; mouse)
Mixed-granulocytic asthma (HDM/CFA-induced; mouse)
Pulmonary fibrosis (Bleomycin-induced; mouse/rat).

Dermatology models – investigate inflammatory skin diseases:

Contact dermatitis (DNFB, TMA, Oxazolone; mouse/rat)
Croton oil-induced irritative dermatitis (mouse/rat)
Imiquimod-induced psoriasis (mouse)
Alopecia shaving/hair growth model (mouse)
Ex vivo human skin explants.

Inflammation-related metabolism models – study inflammation in metabolic contexts:

Diabetes models (mouse/rat)
MASH liver inflammation (mouse/rat)

Inflammatory pain models – explore pain-relieving efficacy in inflammation model: dynamic weight bearing (DWB) in LPS-induced abdominal pain (rat).

In vivo services: In addition to efficacy and PK/PD evaluations, we offer histopathology assessments, in vivo imaging, biomarker analysis and immune profiling in various ex vivo tissues, optimally complementing your preclinical package in accordance with Good Clinical Practice (GCP).

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Our immunology platform

Discover how our cell-based immunology services can enhance your drug discovery process.

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Integrated dermatology

Explore our comprehensive dermatology services tailored to your individual needs.

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in vivo fibrosis and metabolic disease

Respiratory diseases & pulmonary fibrosis

Our scientists support you with tailored solutions for respiratory diseases and pulmonary fibrosis.

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