Metabolism and fibrosis

Approaching metabolic diseases and fibrosis

Nuvisan offers state-of-the-art research services for drug discovery and development in metabolism and fibrosis. We provide comprehensive solutions from early-stage target discovery to preclinical and translational studies, using advanced in vitro and in vivo models to tackle complex metabolic and fibrotic diseases. Our key focus areas include metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, pulmonary fibrosis, diabetes, obesity and disorders of lipid and glucose metabolism.

Translucent human body illustration showcasing key organs involved in metabolic processes.

Capabilities overview

Our metabolism and fibrosis capabilities encompass tailored research solutions, including:

Target discovery and validation: employing bioinformatics, omics platforms, and functional genomics (CRISPR/Cas9)
Preclinical modeling: comprehensive in vitro and in vivo systems to study disease mechanisms and drug effects
Biomarker discovery: identification of predictive, diagnostic and pharmacodynamic biomarkers to inform patient selection and treatment monitoring

Innovative approaches for precision medicine

Our research platforms enable precision medicine strategies for metabolic and fibrotic diseases:

Development of patient-derived cell models to evaluate drug responses
Use of organoids and tissue slices for human-like disease modeling
Comprehensive profiling of metabolic and fibrotic pathways to identify novel intervention points

In vitro models

Human primary cells (hepatocytes, fibroblasts, adipoctes)
iPSC-derived cells (cardiomyocytes, fibroblasts)
Precision-cut tissue slices for liver and lung fibrosis studies
Organoid models for fibrotic disease pathways

In vivo efficacy models

Evaluation of anti-fibrotic and metabolic interventions in disease-relevant models
CCL4- and TAA-induced liver fibrosis models
Bleomycin-induced lung fibrosis in mice and rats
Diet-induced obesity and diabetes models in rodents
Lipid tolerance and glucose metabolism studies
PK/PD assessments and dose optimisation

Analytical platforms and mechanistic studies

Seahorse analyser for metabolic flux analysis
Advanced imaging systems for tissue fibrosis quantification
Proteomics and transcriptomics for biomarker discovery
Pathway analysis and mode-of-action characterisation
Integration of multi-omics data to uncover therapeutic targets

Tailored services for drug development

Nuvisan offers a wide range of off-the-shelf pharmacology models tailored to your research needs, while also providing expert customisation support to develop bespoke solutions for your unique scientific challenges. Trust us to adapt our models to meet your specific requirements, helping ensure precision and reliability in your pharmaceutical research.

Primary cell & ex vivo assays

Discover how our primary cell and ex vivo assays can support you with your research.

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Llung disease models

Our expert scientists join forces to tackle your respiratory disease and pulmonary fibrosis challenges with you.