In vivo pharmacokinetics

PK in rodent and non-rodent species

Our comprehensive in vivo pharmacokinetic (PK) study portfolio supports a broad range of study designs across multiple animal species. Whether optimising compounds and selecting candidates through basic PK assessments or addressing complex, project-specific requirements, our experienced team determines and tailors an effective approach to meet your research and drug development objectives. By utilising serial microsampling techniques, we can generate complete PK profiles from individual animals, even in small species such as mice and rats, with or without excreta collection. Our analytical scientists are skilled in quantifying analytes across diverse biological matrices using advanced mass spectrometry techniques.

PK in genetically modified rodents

Genetically modified rodent models offer valuable tools for evaluating the in vivo roles of drug-metabolising enzymes and transporters and bridging species differences in drug metabolism and disposition using humanised mice. We conduct drug metabolism and pharmacokinetics (DMPK) studies in genetically engineered mice and rats as required to support your drug development efforts.

Species and routes of administration

We work with a variety of animal species, including mice, rats, dogs and genetically modified animals such as mice or rats. Our services encompass various routes of administration, including intravenous (bolus or infusion), oral, subcutaneous, intramuscular, intranasal, intraperitoneal and topical. Other routes of administration and multiple dosing are available upon request.

Formulation development and matrices

We specialise in the development, testing and comparison of different formulations for administration to ensure optimal delivery and efficacy. We analyse a wide range of biological matrices, including blood, plasma, serum, urine, faeces, bile, cerebrospinal fluid and various organs and tissues.

Reports

We deliver standardised or customised study reports based on your specific needs. Whether you require a format ready for upload to your internal database, an abbreviated report, or a submission-ready regulatory document, our team delivers DMPK data in the format that best suits your requirements. Our goal is to provide high-quality data and insights to accelerate and enhance your drug development program.

Animal welfare

High standards of animal welfare that align with the 3R-concept and AAALAC accreditation are the basis of how we conduct our work.