Oncology platform

Various models of tumor-bearing animals allow for in-depth characterization of novel drug candidates, answering many crucial questions for further development. We have hands-on experience with a broad range of > 200 preclinical oncology models in mice and rats. Our scientists can help you design and conduct in vivo pharmacology studies tailored to your specific needs.

We offer a range of xenograft and syngeneic models for multiple cancer indications, including solid and hematological tumor models, metastasis and colonization models, and immuno-oncology models. Our services include various study types, such as tolerability, pharmacokinetic and pharmacodynamic analyses, anti-tumor efficacy, imaging, and radiation. We have experience with small molecules and biologics and offer several analysis options, including tumor growth kinetics, biomarker analysis, and immune cell profiling. Our small animal facility is equipped with radiation and imaging capabilities, including bioluminescence, µCT, and US.

Xenograft and Syngeneic Models for Multiple Indications

  • Subcutaneous and orthotopic
  • Solid and hematological tumor models
  • Metastasis and colonization models
  • Immuno-oncology models
  • Model establishment
  • In vivo model database with response data

Study Types

  • Tolerability
  • Pharmacokinetic (PK) and pharmacodynamic (PD)
  • Anti-tumor efficacy
  • Imaging (bioluminescence, µCT)
  • Radiation
  • Experience with small molecules and biologics

Analysis Options

We have a knowledge base of >  200 oncology preclinical CDX models. A list of available models follows (further models might be available upon request):

Example data:

Subcutaneous cell line derived xenograft (CDX) in mouse