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Hit-to-lead

Expert medicinal chemists for high-quality lead compounds

Our team consistently evaluates hit tractability following large screening campaigns of in-house or customer screening collections. By leveraging modern compound design tools, meticulously crafted screening cascades and state-of-the-art synthetic methods, we generate high-quality lead compounds to drive your discovery efforts forward.

Photochemistry reaction rack using blue LED light source

Our expert chemists help transform hits into leads with speed and precision

Our chemists begin with your hit molecules, whether they emerge from biochemical, cellular, phenotypic, fragment, virtual or other screening methods. During the hit-to-lead phase, we:  

  • utilise extensive medicinal chemistry expertise to vet hit lists  
  • apply in silico prediction tools to help ensure that only the best starting points are advanced
  • triage new derivatives through well-defined characterisation cascades.  

We take pride in our experience with a wide variety of chemistries, including rule-of-five compliant compounds, macrocycles and peptides. Speed of synthesis is paramount during hit-to-lead work, and we employ automation and parallel synthesis whenever possible. Our up-to-date knowledge of heterocyclic and natural product chemistry enables our chemists to design safe and effective synthetic routes, even for the most challenging small-molecule projects.  

Whether ligand- or structure-based design, our creative team of chemists emphasises rapid and broad chemical space expansion to enable the discovery of high-quality, novel chemical matter.

 
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