• contact us navContact Us
  • search navSearch
Let's connect

Want to discuss your project or have any questions?

In vitro DMPK

In vitro DMPK studies for drug discovery

Our in vitro compound profiling services include state-of-the-art assays for metabolic stability (liver microsomes and hepatocytes), metabolite identification, permeability, protein binding, blood partitioning and drug-drug interaction (DDI) studies. We offer rapid, reliable data of the highest quality, along with scientific support for result interpretation and screening strategy recommendations to address ADME challenges.
Two scientists operating large liquid handling machines 

In vitro DMPK for discovery

In vitro DMPK assays are essential in early drug discovery for evaluating the pharmacokinetic properties of potential candidates. These assays predict a drug's behaviour in the body by assessing its absorption, distribution, metabolism and excretion (ADME) characteristics. Cost-effective and time-efficient, in vitro methods allow for the screening of numerous compounds before advancing to in vivo studies. Our key assays include liver microsomal stability tests, cytochrome P450 enzyme assays for metabolic profiling, protein binding studies and permeability tests (e.g., Caco-2 cell model). This data guides chemical structure modifications to optimise bioavailability, reduce toxicity and improve efficacy. Our experienced PhD-level scientists have a strong understanding in interpreting results, integrating them into project contexts, and establishing structure–property relationships. We accommodate your needs, whether for screening services or the design, performance and evaluation of screening cascades. Our in vitro compound profiling services include assays for:

 
v.1.1.1203