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Metabolite ID

Biotransformation and metabolite identification

Metabolism studies are essential for drug discovery, providing critical insights into the safety and efficacy of potential drug candidates. Understanding metabolic pathways is crucial to predict how a drug will behave in humans, identify potential risks and optimise the development process. Investigating differences in metabolic profiles between humans and animal models early on helps detect unique or disproportionate human metabolites, helping ensure more reliable translation of preclinical data to human outcomes.

A collection of HPLC-MS machines arranged on a benchtop, illustrating sophisticated technology for mass spectrometry applications.

Metabolite pathway elucidation for optimised drug discovery

We offer metabolism studies in a screening mode for a broad range of compound classes, enabling rapid and cost-effective evaluation of metabolic profiles. Additionally, upon client request, we provide tailored metabolic identification (Met ID) screening to address the specific needs of individual compounds, offering a customised approach that aligns with the unique requirements of each project.

A collection of closed lab vials containing samples of urine, arranged neatly for analysis in a laboratory setting.

Understanding your lead candidate´s metabolism

At Nuvisan, we support metabolite profiling at all stages of your drug discovery projects. Understanding the metabolites of your drug molecule is crucial for interpreting data and optimising its pharmacological, pharmacokinetic and toxicological properties. Before full characterisation of your candidate across different species becomes critical, it is essential to assess the metabolic liabilities of your molecules. This early insight helps your chemists make informed decisions during the hit-to-lead and lead optimisation phases.  

We assist you efficiently in identifying the metabolic soft spots of your molecules, helping provide insights into the structural elements that contribute to metabolic liabilities.  
 
Our services include metabolic stability screening assays, custom-designed in vitro experiments and analysis of pharmacokinetic in vivo samples. We determine the metabolic soft-spot profile of your compound, offering structural elucidation of metabolites and proposed biotransformation reactions, focusing on the five most abundant metabolites.  

For advanced projects, we provide in-depth characterisation of your molecule's metabolic profile, comparison of metabolites across species and identification of metabolites from in vivo pharmacokinetic studies in preclinical species.

 
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