Technology Platforms

NUVISAN combines excellent disease and target biology expertise with our state-of-the-art technology platforms, which support your drug discovery project independently of the indication and modality. Functional readouts, such as cellular phenotypic drug responses, are monitored by high-content assays, Meso Scale Discovery, and multiparametric flow cytometry (FACS). Next-generation sequencing (NGS) and single-cell sequencing (scseq) provide mode of action analysis at unprecedented resolutions.

Multicolor Flow Cytometry

Multicolor flow cytometry is a valuable tool in drug discovery for identifying new drug targets, screening potential drug candidates, and analyzing the effects of drugs on specific cell populations.

We offer comprehensive panels for immunoprofiling. Assays for all major mouse and human immune cell populations are established and validated.


  • Cytek Aurora (full-spectrum technology)
  • BD Canto II
  • Miltenyi MACSQuant X
  • Sartorius Intellicyt iQueScreener PLUS
  • Sony MA900 cell sorter


  • Immuno-oncology
  • Biomarker identification and validation
  • Target identification and validation
  • Compound MoA and efficacy
  • Immunoprofiling
  • Cell proliferation/killing assays
  • Cytokine and functional profiling
  • Antibody screening
  • Cell line development
  • Primary cell screening
  • Monitoring of treatment efficacy
  • Phosphorylation assays
  • Cell sorting for subsequent single-cell sequencing
  • Immunophenotyping of all immune cell populations
    • Immune subsets of T, B, and NK cells
    • Regulatory T cells
    • Naïve T cells
    • Activated T cells
    • Memory and effector T cells
    • Naïve and memory B cells
    • Nonclassical and classical monocytes, MΦ, DCs
    • Room for extra markers/dyes according to tailored scientific investigations


  • Fit-for-purpose assay validation, comprising specificity, range of detection, pre-analytics, sample stability, and reproducibility
  • Panel design (> 25 parameters)
  • High-throughput screening
  • Preparation of samples (solid or liquid tissues)
  • QC and acquisition
  • Data analysis (manual gating and unsupervised clustering)

Next-Generation Sequencing Platform

Our NGS services are tailored to your specific requirements, including experimental design, professional execution in the lab, in-house NGS sequencing, and customized bioinformatics analysis—all integrated at our site in Berlin.

We provide state-of-the-art NGS technology for the identification of novel targets and the analysis of the mode of action of compounds at unprecedented resolution. 10x Genomics single-cell sequencing is also well suited for the measurement of exploratory biomarkers in preclinical and clinical studies.

Selected services from our portfolio comprise:

  • DNA and RNA isolation services
  • transcriptome sequencing (RNA-seq)
  • genome sequencing
  • exome sequencing
  • epigenetic profiling
    • ChiP-seq
    • methylome-seq
    • ATAC-seq
  • amplicon and panel sequencing
  • barcode-seq (e.g., for CRISPR screening, AAV, and LNP tissue distribution)
  • 10x Genomics single-cell sequencing
    • scRNA-seq (3′ and 5′ RNA workflows)
    • scATAC-seq
    • T-and B cell receptor profiling
    • CITE-seq
    • perturbation-seq (CRISPR ko or CRISPRi combined with single-cell sequencing)
    • custom scAmplicon-seq

Please inquire for further information here.