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Cell-based assays

Therapeutically relevant cell-based assays for drug discovery and development

Cell-based assays provide a relevant biological context, making them crucial for discovery and development. Our biology team supports you with disease-relevant in vitro and in vivo models to identify leads and targets, including high-throughput formats, using a variety of proprietary chemical libraries. We also establish your drug candidate's structure-activity relationships, validate signalling pathways and mechanisms of action and identify biomarker candidates to help ensure the success of your project.
three lab technicians working at the clean bench.

Dedicated to providing high-quality data

Nuvisan offers state-of-the-art in vitro safety facilities (S1 and S2), supporting all phases of drug discovery and development. Our expertise spans various disease areas and modalities, with a proven track record of translating programs into the clinic. We provide a broad assay repertoire, from single-parameter assays (e.g., ATP production) to complex readouts (e.g., high-content imaging, flow cytometry, next-generation and single-cell sequencing). Our  ready-to-use solutions help you to develop scalable, customised assays tailored to your specific needs.
High-throughput, high-content analysis of advanced cell models.

Cell-line platform

Our cell-line platform operates with a wide range of cell systems, including established cell lines, primary cells and iPSCs. Collaborating with our advanced technology platforms, we offer off-the-shelf solutions like reporter cell lines and 2D single-cell cultures. Additionally, we develop complex co-cultures and organoids as disease-relevant human translational cell systems.

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High-throughput assay systems  

To monitor cellular phenotypic drug responses, Nuvisan’s state-of-the-art infrastructure supports the development of classical end-point assays, kinetic readouts in living cells, high-content assays, Meso Scale Discovery (MSD), precision protein analysis, and multiparametric flow cytometry and FACS. Our next-generation sequencing (NGS) and single-cell sequencing services offer mode-of-action analysis at excellent resolutions. 

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Advanced cellular assays

Our team provides specialised assays and collaborative support to refine hit lists, optimise leads and enhance your understanding of compound behaviour through comprehensive off-target, species selectivity, cell-based, biophysical and biochemical analyses.

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Human induced pluripotent stem cells   

Using patient-derived or gene-edited human iPSCs enables advanced study of human disease. They preserve the donor’s genetic profile and closely resemble actual human cells, making them crucial for current drug development processes.

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Primary cell assays  

To reduce development risks and enhance success rates, we prioritise the translational value of models early on. Primary cells or tissues from human donors and animals are essential components of our drug discovery and profiling efforts.

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Functional and mechanistic assays    

Understanding disease mechanisms is vital, and our mode-of-action assays provide precise research tools. Explore our extensive range of cell-based functional and mechanistic assays that support your drug discovery projects. 

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Immunology platform  

This platform offers advanced immunoassays and inflammation models to support your immunology research and development projects across various therapeutic areas, including oncology, inflammation, cardiology, neurology, obesity, diabetes women’s health and metabolic disorders.  

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Technology platforms    

Our expertise in disease and target biology, supported by advanced technology platforms, enhances drug discovery across all indications. We monitor functional readouts and provide high-resolution mode-of-action analysis using cutting-edge sequencing services.

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Stack of microplates with purple and yellow wells used for laboratory assays.

Assays2Go platform

Our Assays2Go services help enhance your drug discovery process.

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Arm of screening robot transfers 384-well plate

HTS solutions

Our comprehensive high-throughput screening services can support you with the identification of your hit molecules.

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