• contact us navContact Us
  • search navSearch
Let's connect

Want to discuss your project or have any questions?

Isothermal titration calorimetry

Nuvisan’s isothermal titration calorimetry platform

Isothermal titration calorimetry (ITC) provides precise ligand-binding affinities and thermodynamic insights, with personalised support from our biophysics team for your experiments. ITC is considered the gold standard for measuring ligand-binding affinities in solution without labels. Beyond binding affinities, ITC reveals crucial thermodynamic parameters, including enthalpy (ΔH) and entropy (ΔS), offering insights into molecular binding from a single experiment. Our biophysics team supports you in designing and performing ITC experiments tailored to your individual needs.

Scientist setting up the instrument for ITC measurements

Thermodynamic insights into molecular binding

Our experienced scientists leverage isothermal titration calorimetry (ITC) to provide you with direct insights into the thermodynamics of binding events. ITC uniquely determines key parameters – enthalpy (ΔH), entropy (ΔS), free energy (ΔG), steady-state affinity (KD) and stoichiometry – in a single experiment. Our experts offer precise analysis without requiring modifications to your molecules, using a broad range of buffer compositions to suit your specific needs. We support you in profiling hit clusters, stereoisomers and hit-to-lead projects, and in nominating hits for structural biology. Our team also characterises RNA–ligand binding through ITC.

Related topics & resources

Technician prepares Biacore 8K for sample measurement

Surface plasmon resonance

Nuvisan's surface plasmon resonance (SPR) services deliver real-time analysis of biomolecular interactions.

learn more
Scientist verifying DSF data in the laboratory 

DSF/TSA & NanoDSF

Explore how our DSF/TSA and NanoDSF solutions can shed light on the thermal stability of your biomolecules.

learn more
Laboratory researcher preparing capillaries for measurements on an MST instrument

Microscale thermophoresis

We perform MST experiments to support our clients with the analysis of interactions between biomolecules.

learn more
 
v.1.1.1203