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Nuclear magnetic resonance

Validate and characterise chemical matter with powerful NMR solutions  

Nuclear magnetic resonance (NMR) spectroscopy is essential in structural biology for revealing the 3D structures of proteins, nucleic acids and their complexes. It provides detailed insights into molecular dynamics, interactions and conformational changes. NMR aids in validating target engagement, identifying and characterising chemical compounds confirming initial hits. 

High-throughput NMR measurements using a SampleJet

A powerful and versatile in-solution biophysical technique 

At Nuvisan, we leverage our extensive expertise and advanced NMR capabilities to build confidence and guide your project. We offer NMR-based fragment screening, from identifying initial hits to conducting confirmation and analogue studies, ensuring comprehensive support. Additionally, we provide early biophysical verification of ligand binding to cryo-EM protein constructs under conditions similar to cryo-EM environments.  

High-throughput NMR measurements using a SampleJet

Protein-observed NMR 

Our robust and information-rich protein-observed NMR methods can help you validate and characterise the binding of your compounds to their targets. We provide binding site identification for targets whose NMR signals have been assigned to their respective amino acids. Additionally, we offer further characterisation, including determining ligand binding affinity, protein folding and dynamics, and assessing overall protein sample quality and stability, helping ensure you receive precise and reliable insights for your drug discovery projects. 

Ligand-observed NMR  

Ligand-observed NMR is the method of choice for target engagement studies involving larger targets or those without available labelling schemes. An added advantage of ligand-observed NMR is its requirement for lower amounts of protein, making it an efficient and effective solution for your research needs. 

NMR platform 

Our NMR equipment includes two 600-MHz Bruker instruments equipped with cryo-cooled probes for enhanced sensitivity and automatic sample changers for high-throughput measurements. The fast, automated preparation of low-volume samples, combined with the cooling of sensitive samples, makes our setup ideal for protein–ligand interaction studies by NMR. 

Related topics & resources

Discussing new lead optimization strategies identified from a new target-compound structure.

Structural biology solutions

Our structural biology team delivers high quality 3D information of your compounds of interest to guide the design of improved chemical matter.

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Placing samples into the instrument for SPR analysis

Biophysics solutions

We support you with in-depth analysis of compound-target interactions with our biophysics toolbox. 

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E3 Ligase and 4 examples of fragment hits

Fragment screening

We perform fragment screening via SPR, NMR, TSA, MS and HTX.

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