Neuroscience

Neurology and pain research expertise

Our multidisciplinary team specialises in CNS/PNS drug discovery, offering comprehensive services across preclinical and translational stages. With an integrated platform, we advance projects efficiently by combining in vitro, in vivo and ex vivo models tailored to neurological and pain conditions.

Human body with glowing red pain points on neural pathways illustrating pain or nerve stimulation

Target validation and disease models

We provide state-of-the-art target validation services using advanced tools such as:

CRISPR screening and target deconvolution
iPSC-derived neurons (e.g., dopaminergic neurons, sensory neurons), glial cells (e.g., microglia) and 3D brain organoids (cortical and midbrain)
Proprietary disease models for pain, neurodegeneration and inflammation, including neuropathic pain, stroke and traumatic brain injury (TBI)
In vivo models designed to replicate human conditions with high translational relevance, supported by extensive imaging and biomarker capabilities

Detailed visualization of brain organoids with embedded AI and neural networks, representing organoid intelligence

In vitro and ex vivo platforms

Leverage our cutting-edge technologies for mode-of-action studies and compound profiling:

High-content imaging and functional readouts (e.g., neuronal activity and viability)
Biomarker discovery using genomics, proteomics, and spatial profiling
Custom assay development for neuroinflammation and synaptic activity

Translational biomarker services

We bridge preclinical findings to clinical applications through:

Biomarker indication profiling from CNS and pain models
Validation in human tissues and biobank-based analysis
Integration of pharmacokinetic/pharmacodynamic (PK/PD) relationships to optimise dosing and efficacy

Key capabilities

Our neurology-focused capabilities include:

Microelectrode array (MEA) with the Axion Maestro Pro for functional analyses of excitable cells
Advanced imaging techniques: in vivo bioluminescence, fluorescence and µCT
Assay-ready organoid systems for Alzheimer’s and Parkinson’s disease studies
Quantitative PCR and proteomics for myelin protein assessment

Related topics & resources

The “strings” of the heart that contract and relax with every beat.

Human stem cell platform

We are constantly expanding our hiPSC-derived cell portfolio in the cardiology and neurology indication spaces.

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Lab technician operating a FLIPR® Penta reader

Cellular high throughput assays

Our high-throughput screening (HTS)-compatible cell-based assays can be developed to HTS standards, accommodating up to 384-well or 1,536-well microtiter plate formats.

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Fibrillating heart in a medical imaging study

Cardiovascular diseases

Take a look at our expertise and tailored solutions in the cardiovascular field.

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