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Cardiovascular diseases

Our cardiovascular expertise 

At Nuvisan, we specialise in advancing drug discovery and development for cardiovascular diseases through comprehensive and integrated research services. Our capabilities span from target identification and validation to preclinical development and clinical translation. With state-of-the-art technologies and multidisciplinary expertise, we address critical challenges in cardiovascular drug development. 

Fibrillating heart in a medical imaging study

Capabilities overview 

Our cardiovascular research services offer end-to-end solutions, including: 

  • Target identification and validation: employing functional genomics (CRISPR/Cas9), bioinformatics and omics analyses to identify and validate novel targets
  • In vitro assay development: tailored cell models, including human iPSC-derived cardiac cells for mechanistic and pathway analyses.
Stylised image of DNA editing using CRISPR 

CV technology platform 

Our technology platforms support research in the fields of: 

  • Hereditary cardiac disease 
  • Arrhythmias and heart failure 
  • Cardiac fibrosis 

We support your cardiovascular projects with: 

Human iPSC-derived cell models 

  • Ventricular and atrial cardiomyocytes 
  • Cardiac fibroblasts
  •  Cardiac endothelial cells 
  • 3D engineered cardiac organoids (ECOs) 

 

Imaging and analysis 

  • Multi-electrode array (MEA) for electrophysiological studies 
  • Impedance-based endothelial/epithelial barrier assays 
  • Non-invasive imaging platforms for functional assessments

 

High-throughput screening

  • Screening of small and large molecule libraries, including fragment-based and virtual approaches 
  • High-content imaging with advanced imaging systems for live-cell analysis and phenotypic screening

 

Metabolic profiling: Seahorse analyser for mitochondrial and cellular energetics

 
 

 

 

 

Related topics & resources

The “strings” of the heart that contract and relax with every beat.

Human stem cell platform

We are constantly expanding our hiPSC-derived cell portfolio in the cardiology and neurology indication spaces.

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MACS Quant Flow Cytometer in action

Immunology platform

Explore how our scientists support your research projects with our immunology platform.

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Translucent human body illustration showcasing key organs involved in metabolic processes.

Neuroscience

Discover our service portfolio in the neuroscience field.

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