The crop protection industry plays a central role in modern agriculture, helping efficiently and safely to feed a growing world population. Farmers across the globe routinely access a range of chemical, biological and digital technologies to achieve this goal. However, research and development activities aimed at integrating these offerings and developing new innovative agrochemical solutions are becoming increasingly complex. NUVISAN offers a range of agrochemical R&D solutions to help you address specific questions or tasks during discovery and development stages. Before chemistry begins, our experts in target discovery and discovery biosciences can help you validate new fungal, plant or insect protein targets, express and characterize target protein and develop biochemical, cellular, and high-content assays. Whole-organism screening approaches for agrochemical hit finding are the industry standard, yet many approaches utilized regularly by biopharma can bring great value to the agrochemical discovery process. Virtual, fragment and high-throughput screening – using NUVISAN´s Explorer Library – can help you find unique chemical matter to prevail in crowded IP landscapes or overcome regulatory challenges on known chemistries.
Chemistry conducted inside (Life Science Chemistry) and outside the lab (Digital Life Chemistry) can help transform new hits into viable leads, quickly generate SAR (structure-activity-relationships), for example, using plate-based chemistry approaches, or even produce relevant metabolites needed during toxicological or consumer safety studies. A team of chemoinformaticians is involved in these activities at various stages to ensure high-quality experimental design and thorough data analysis. Understanding the absorption, distribution, metabolism, excretion (ADME) properties is a crucial first step in designing high-quality safety studies. NUVISAN has a range of in vitro assays to interrogate ADME properties using both radio- / non-labeled material. In vivo PK in, e.g. rodent models as single compounds & cassette dosing and using different administration routes can also be conducted. Our scientists can also help you understand key biotransformations or identify various key metabolites using a range of in vitro and in vivo metabolite profiling platforms.
With over four decades of experience in toxicology testing, we can quickly develop a solution tailored to your agrochemical project needs. Lead compounds can be studied using a variety of in vitro and in vivo toxicological methods, for example, using AMES assays or within in vivo rodent studies to assess genotoxicity. In pathology, the effects of agrochemicals can be assessed clinically – through analysis of clinical chemistry, hemostasis, hematology & urine parameters – and via post-mortem examination of organs, both microscopic and macroscopic.
NUVISAN can help to develop a safe and economical production concept for your agrochemical active ingredient. Our process development and kg-batch manufacturing facilities are co-localized, and routinely conduct route evaluation, selection and scale-up to prepare up to 10 kg quantities of active ingredient. We also assist in other important aspects of chemical development such as solid-phase investigations (e.g. polymorphs, salts, co-crystals, or amorphous forms) or impurity identification.
